Overview

Test Name

TPMT Genotyping

Test Code

SG1004

Test Category

Single Gene Tests

Test Subcategory

Pharmacogenomic

Disease(s) Targeted

TPMT

Who Is The Test For?

Patients who may be considered for a prescription of thiopurine drug treatment. To identify the risk of drug-related toxicity.

Variants

TPMT*2, TPMT*3B, TPMT*3C

Deliverables

Clinical Report (Download a sample report here)

Turnaround Time

2-3 weeks

Specimen Requirements

For detailed information about the sample requirements, please consult our clinical sample requirements page.

*Turnaround times are estimated from receipt of satisfactory specimen and test request form at the laboratory to release of clinical report. The turnaround time may vary depending on the nature of the specimen and the complexity of the investigation required. The above table is only a guideline and the complexity of a case and the requirement for further investigations may change this.

About TPMT

Variants in the TPMT (thiopurine S-methyltransferase) gene can impair the metabolism of thiopurine drugs leading to an increased risk of drug-related toxicity. Genetic testing for TPMT variants is essential for guiding thiopurine dosing and reducing the risk of serious side effects by allowing clinicians to personalise treatment plans, such as dose adjustment.