Membranoproliferative Glomerulonephritis including C3 Glomerulopathy Panel

Membranoproliferative glomerulonephritis (MPGN) is a kidney disease characterized by specific injury patterns on a kidney biopsy, including mesangial cell proliferation and thickening of the glomerular basement membrane. The prevalence of MPGN is low, accounting for about 1 to 3% of all kidney biopsy diagnoses. C3 Glomerulopathy (C3G) is a subtype of MPGN caused by a defect in the complement system, a part of the immune system, which results in the deposition of excess C3 protein in the glomeruli. C3G is a complex genetic disorder that is rarely inherited in a simple mendelian fashion. Multiple affected persons within a single nuclear family are reported only occasionally, with both dominant and recessive inheritance being described. There are multiple genes that are associated with C3G, mainly CFH, C3, and CFI, which account for 12%, 11% and 5% of reported cases, respectively.