Overview

Test Name

Hereditary Renal Cancer Panel

Test Code

HCE1012

Test Category

Gene Panels

Test Subcategory

Hereditary Cancer

Disease(s) Targeted

Renal Cancer

Who Is The Test For?

Patients with a family history, clinical suspicion, or diagnosis of renal cancer

Test Approach

Whole exome sequencing (WES) with in silico gene panel analysis

No. of Genes

20

Panel Content

BAP1, CDKN2B, EPCAM, FH, FLCN, MET, MITF, MLH1, MSH2, MSH6, PMS2, PTEN, SDHB, SDHC, SDHD, TMEM127, TP53, TSC1, TSC2, VHL

Mitochondrial Genome Included In The Analysis

No

Deliverables

Clinical Report (Download a sample report here)

Turnaround Time

~3-6 weeks*

Specimen Requirements

For detailed information about the sample requirements, please consult our clinical sample requirements page.

*Turnaround times are estimated from receipt of satisfactory specimen and test request form at the laboratory to release of clinical report. The turnaround time may vary depending on the nature of the specimen and the complexity of the investigation required. The above table is only a guideline and the complexity of a case and the requirement for further investigations may change this.

About Renal Cancer

Hereditary renal cancer is rare, accounting for approximately 3-8% of all kidney cancers, though this number may be an underestimate. In contrast to the more common sporadic (non-inherited) kidney cancers, hereditary cases often manifest at an earlier age, can present as multiple tumors (multifocal), and may affect both kidneys (bilateral).

The most common genetic causes involve variants in the VHL gene (von Hippel-Lindau syndrome), FH gene (hereditary leiomyomatosis and renal cell cancer), FLCN gene (Birt-Hogg-Dubé syndrome), and SDHx genes (paraganglioma-pheochromocytoma syndromes), which are often tumor suppressor genes.