Hereditary Cancer - Lynch Syndrome Panel

Overview

Test Name

Hereditary Cancer - Lynch Syndrome Panel

Test Code

HCE1003b

Test Category

Gene Panels

Test Subcategory

Hereditary Cancer

Disease(s) Targeted

Lynch Syndrome

Who Is The Test For?

Patients with a family history, clinical suspicion, or diagnosis of Lynch syndrome.

Test Approach

Whole exome sequencing (WES) with in silico gene panel analysis

No. of Genes

Panel Content

EPCAM, MLH1, MSH2, MSH6, PMS2

Deliverables

Clinical Report (Download a sample report here)

Turnaround Time

~3-6 weeks*

Specimen Requirements

For detailed information about the sample requirements, please consult our clinical sample requirements page.

Alternative Panels Available

This is a subpanel based on our Hereditary Colorectal Cancer and Polyposis Panel.

*Turnaround times are estimated from receipt of satisfactory specimen and test request form at the laboratory to release of clinical report. The turnaround time may vary depending on the nature of the specimen and the complexity of the investigation required. The above table is only a guideline and the complexity of a case and the requirement for further investigations may change this.

About Lynch Syndrome

Lynch Syndrome, also referred as Hereditary Nonpolyposis Colorectal Cancer (HNPCC), is the most common hereditary colorectal cancer syndrome, accounting for about 3-5% of all cases. People with Lynch syndrome have a significantly increased risk of developing colorectal cancer, often before the age of 50. It is associated with variants in DNA mismatch repair (MMR) genes like MLH1, MSH2, MSH6, and PMS2, or a deletion in EPCAM gene.