Overview

Test Name

Hereditary Cancer - BRCA1/BRCA2

Test Code

HCE1001b

Test Category

Gene Panels

Test Subcategory

Hereditary Cancer

Disease(s) Targeted

cancer

Who Is The Test For?

Patients with a family history, clinical suspicion, or diagnosis of cancer.

Test Approach

Whole exome sequencing (WES) with in silico gene panel analysis.

No. of Genes

Panel Content

BRCA1, BRCA2

Deliverables

Clinical Report (Download a sample report here)

Turnaround Time

~3-6 Weeks*

Specimen Requirements

For detailed information about the sample requirements, please consult our clinical sample requirements page.

Alternative Panels Available

This is a subpanel based on our Hereditary Breast Cancer Panel.

*Turnaround times are estimated from receipt of satisfactory specimen and test request form at the laboratory to release of clinical report. The turnaround time may vary depending on the nature of the specimen and the complexity of the investigation required. The above table is only a guideline and the complexity of a case and the requirement for further investigations may change this.

About cancer

This panel includes only BRCA1 and BRCA2 genes. BRCA1- and BRCA2-associated hereditary breast and ovarian cancer (HBOC) is characterized by an increased risk for female and male breast cancer (primarily BRCA2) , ovarian cancer (including fallopian tube and primary peritoneal cancers), and to a lesser extent other cancers such as prostate cancer, pancreatic cancer, and melanoma primarily in individuals with a BRCA2 pathogenic variant.

The prevalence of BRCA1 and BRCA2 pathogenic variants in the general population is estimated at 1 in 100-200.BRCA1- and BRCA2-associated HBOC is inherited in an autosomal dominant manner. The vast majority of individuals with a BRCA1 or BRCA2 pathogenic variant inherit it from a parent. However, because the penetrance of breast, ovarian, and other cancers associated with pathogenic variants in BRCA1 and BRCA2 is less than 100%, not all individuals with a BRCA1 or BRCA2 pathogenic variant have a parent affected with cancer.