Overview

Test Name

Hereditary Breast Cancer Panel

Test Code

HCE1001

Test Category

Gene Panels

Test Subcategory

Hereditary Cancer

Disease(s) Targeted

Hereditary Breast Cancer

Who Is The Test For?

Patients with a family history, clinical suspicion, or diagnosis of breast cancer

Test Approach

Whole exome sequencing (WES) with in silico gene panel analysis

No. of Genes

Panel Content

BRCA1, BRCA2, CDH1, PALB2, PTEN, RECQL, STK11, TP53

Mitochondrial Genome Included In The Analysis

Deliverables

Clinical Report (Download a sample report here)

Turnaround Time

~3-6 weeks*

Specimen Requirements

For detailed information about the sample requirements, please consult our clinical sample requirements page.

*Turnaround times are estimated from receipt of satisfactory specimen and test request form at the laboratory to release of clinical report. The turnaround time may vary depending on the nature of the specimen and the complexity of the investigation required. The above table is only a guideline and the complexity of a case and the requirement for further investigations may change this.

About Hereditary Breast Cancer

Hereditary breast cancer refers to breast cancer that is caused by inherited genetic variants. These variants significantly increase the risk of developing breast cancer and can be passed from parents to their children.

Approximately 5-10% of all breast cancers are hereditary. The most common cause is an inherited variant in the BRCA1 or BRCA2 genes, but other high-risk genes include TP53 (Li-Fraumeni syndrome), PTEN (Cowden syndrome), and STK11 (Peutz-Jeghers syndrome), while moderate-risk genes include PALB2, and CDH1. The prevalence of BRCA1 and BRCA2 pathogenic variants in the general population is estimated at 1 in 100-200.