Overview

Test Name

Comprehensive Hereditary Cancer Panel

Test Code

HCE1004

Test Category

Gene Panels

Test Subcategory

Hereditary Cancer

Disease(s) Targeted

Hereditary Cancer

Who Is The Test For?

Patients with a family history, clinical suspicion, or diagnosis of Cancer

Test Approach

Whole exome sequencing (WES) with in silico gene panel analysis

No. of Genes

134

Panel Content

ABRAXAS1, ACD, AIP, AKT1, ALK, APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRAF, BRCA1, BRCA2, BRIP1, CBL, CDC73, CDH1, CDK4, CDKN1B, CDKN2A, CDKN2B, CHEK2, CTC1, CTNNA1, DDB2, DICER1, DKC1, EGFR, EPCAM, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, EXT1, EXT2, FAM111B, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, FANCM, FH, FLCN, GREM1, HOXB13, HRAS, KIF1B, KIT, KITLG, KRAS, LZTR1, MAP2K1, MAP2K2, MAX, MBD4, MEN1, MET, MITF, MLH1, MLH3, MRE11, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NF2, NRAS, NTHL1, PALB2, PARN, PDGFRA, PHOX2B, PMS2, POLD1, POLE, POLH, POT1, PPP1CB, PRKAR1A, PRSS1, PTCH1, PTEN, PTPN11, RAD50, RAD51C, RAD51D, RAF1, RB1, RECQL, RET, RIT1, RNF43, RTEL1, SDHA, SDHAF2, SDHB, SDHC, SDHD, SHOC2, SLX4, SMAD4, SMARCA4, SMARCB1, SMARCE1, SOS1, SOS2, SPINK1, SPRED1, STK11, SUFU, TERC, TERF2IP, TERT, TINF2, TMEM127, TP53, TSC1, TSC2, VHL, WRAP53, WRN, WT1, XPA, XPC, XRCC2

Mitochondrial Genome Included In The Analysis

Deliverables

Clinical Report (Download a sample report here)

Turnaround Time

~3-6 weeks*

Specimen Requirements

For detailed information about the sample requirements, please consult our clinical sample requirements page.

*Turnaround times are estimated from receipt of satisfactory specimen and test request form at the laboratory to release of clinical report. The turnaround time may vary depending on the nature of the specimen and the complexity of the investigation required. The above table is only a guideline and the complexity of a case and the requirement for further investigations may change this.

About Hereditary Cancer

Hereditary cancer is caused by an inherited genetic variant passed down through families, which increases the risk of developing certain cancers, typically accounting for 5-10% of most cancer cases. Common hereditary cancers include breast, ovarian, and colorectal cancer. Hereditary cancers are often linked to inherited variants in genes that help control cell growth and division. Well-known examples are the BRCA1/BRCA2 genes for breast and ovarian cancer, and the APC gene for Familial Adenomatous Polyposis (FAP) of the colon.

This comprehensive panel includes genes associated with the following cancers among others:

Hereditary Colorectal Cancer and Polyposis

Hereditary Breast and Gynaecological Cancer

Hereditary Endocrine Cancer

Hereditary Gastrointestinal Cancer

Hereditary Lung Cancer

Hereditary Melanoma and Skin Cancer

Hereditary Pancreatic Cancer

Hereditary Paraganglioma and Pheochromocytoma

Hereditary Prostate Cance

Hereditary Renal Cancer

Neurofibromatosis and genes associated with differential diagnosis

Retinoblastoma

Tuberous Sclerosis

Xeroderma Pigmentosum

This panel also includes genes associated with hereditary syndromes with an increased risk of other cancers (e.g. sarcoma, leukemia and lymphoma), such as Li-Fraumeni syndrome (TP53), ataxia telangiectasia (ATM), Bloom syndrome (BLM), neurofibromatosis type 1 (NF1) and less frequently Noonan syndrome (PTPN11, CBL).