Hereditary Cancer Gene Panel Services
Genetic Testing in Hereditary Cancer
Cancer is a leading cause of death worldwide and it has been estimated that 5-10% of all cancers are hereditary i.e. passed down from one generation to the next. Genetic Testing for the presence of germline genetic variants provides many benefits to patients and their family members and forms an important part of cancer care.
Genetic testing for hereditary cancer can help you, the healthcare practitioner, to:
- Identify patients who are at risk of developing cancer, enabling them to take preventative measures where possible.
- Closely monitor patients with a known cancer predisposition thereby facilitating early detection and treatment, which is known to have a positive impact on patient outcomes.
- Identify and access targeted therapies that may benefit your patient.
- Identify family members who may also be a risk, roll out cascade testing, and begin taking preventative measures where appropriate.
- Direct your patients towards helpful patient resources and support groups.
- Assist your patients with family planning.
Hereditary Cancer Gene Panel Tests available at Genseq
Genseq offer a range of Hereditary Cancer gene panels (see table below). These are in silico panels based on whole exome sequencing (WES) data. All panels include single nucleotide variants (SNV), small insertions/deletions (indels), and copy number variation (CNV) analysis.
Test Code
HCE1001
Test Name
Hereditary Breast Cancer Panel
No. of Genes
8
Panel Content
BRCA1, BRCA2, CDH1, PALB2, PTEN, RECQL, STK11, TP53
Test Code
HCE1002
Test Name
Hereditary Breast and Gynaecological Cancer Panel
No. of Genes
28
Panel Content
ATM, BARD1, BLM, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, DICER1, EPCAM, FANCM, MLH1, MRE11A, MSH2, MSH6, NBN, NF1, PALB2, PMS2, PTEN, RAD50, RAD51C, RAD51D, RECQL, SMARCA4, STK11, TP53, XRCC2
Test Code
HCE1001b
Test Name
Hereditary Cancer - BRCA1/BRCA2
No. of Genes
2
Panel Content
BRCA1, BRCA2
Test Code
HCE1003b
Test Name
Hereditary Cancer - Lynch Syndrome Panel
No. of Genes
5
Panel Content
EPCAM, MLH1, MSH2, MSH6, PMS2
Test Code
HCE1003
Test Name
Hereditary Colorectal Cancer and Polyposis Panel
No. of Genes
21
Panel Content
APC, AXIN2, BLM, BMPRIA, CDH1A, EPCAM, GREM1, MBD4, MLH1, MSH2, MSH3, MSH6, MUTYH1, NTHL1, PMS2, POLD1, POLE, PTEN, SMAD4, STK11, TP53