Left Ventricular Noncompaction Cardiomyopathy (LVNC) Panel

Overview

Test Name

Left Ventricular Noncompaction Cardiomyopathy (LVNC) Panel

Test Code

CAE1012

Test Category

Gene Panels

Test Subcategory

Cardiology

Disease(s) Targeted

Left Ventricular Noncompaction Cardiomyopathy (LVNC)

Who Is The Test For?

Patients with a family history, clinical suspicion, or diagnosis of Left Ventricular Noncompaction Cardiomyopathy (LVNC).

Test Approach

Whole exome sequencing (WES) with in silico gene panel analysis

No. Of Genes

Panel Content

ACTC1, DTNA, HCN4, LDB3, MIB1, MYBPC3, MYH7, NKX2-5, PRDM16, RYR2, TAFAZZIN, TBX5, TNNT2, TPM1, TTN

Mitochondrial Genome Included In The Analysis

Deliverables

Clinical Report (Download a sample report here)

Turnaround Time

~3-6 weeks*

Specimen Requirements

For detailed information about the sample requirements, please consult our clinical sample requirements page.

*Turnaround times are estimated from receipt of satisfactory specimen and test request form at the laboratory to release of clinical report. The turnaround time may vary depending on the nature of the specimen and the complexity of the investigation required. The above table is only a guideline and the complexity of a case and the requirement for further investigations may change this.

About Left Ventricular Noncompaction Cardiomyopathy (LVNC)

Left ventricular noncompaction or 'spongy myocardium' is a rare congenital cardiomyopathy that can be diagnosed at any age. It is characterised by a thin, compacted epicardial layer and an extensive noncompacted endocardial layer with prominent trabeculation and deep recesses that communicate with the left ventricular cavity, but not with the coronary circulation. Based on echocardiographic studies, reported prevalence is between 0.014% and 1.3% in the general population

It has been classified as a primary cardiomyopathy of genetic origin that usually affects the left ventricle; however, right ventricular and biventricular non-compaction have also been described. It can be associated with neuromuscular disorders, cardiac structural abnormalities, and chromosomal defects.