Overview

Test Name

Comprehensive Cardiac Arrhythmias Panel

Test Code

CAE1005

Test Category

Gene Panels

Test Subcategory

Cardiology

Disease(s) Targeted

Cardiac Arrhythmias

Who Is The Test For?

Patients with a family history, clinical suspicion, or diagnosis of a Cardiac Arrhythmia.

Test Approach

Whole exome sequencing (WES) with in silico gene panel analysis

No. Of Genes

Panel Content

AKAP9, ANK2, CACNA1C, CACNB2, CALM1, CALM2, CALM3, CASQ2, CAV3, CDH2, CTNNA3, DES, DSC2, DSG2, DSP, FLNC, GPD1L, HCN4, JUP, KCND3, KCNE1, KCNE2, KCNE3, KCNH2, KCNJ2, KCNJ5, KCNQ1, LMNA, PKP2, PLN, RYR2, SCN1B, SCN2B, SCN3B, SCN4B, SCN5A, SLC4A3, SNTA1, TECRL, TGFB3, TMEM43, TRDN, TRPM4

Mitochondrial Genome Included In The Analysis

Deliverables

Clinical Report (Download a sample report here)

Turnaround Time

~3-6 weeks*

Specimen Requirements

For detailed information about the sample requirements, please consult our clinical sample requirements page.

*Turnaround times are estimated from receipt of satisfactory specimen and test request form at the laboratory to release of clinical report. The turnaround time may vary depending on the nature of the specimen and the complexity of the investigation required. The above table is only a guideline and the complexity of a case and the requirement for further investigations may change this.

About Cardiac Arrhythmias

Arrhythmia is an abnormal rhythm of the heart. The only normal rhythm of the heart is a normal sinus rhythm. In this rhythm, an impulse is generated in the sinoatrial (SA) node, which is conducted through and slowed down while passing through the atrioventricular node (AV). It is then conducted through the bundle of His, to the left and right bundle branches, and eventually into the Purkinje fibers. Any deviation from this conduction pathway results in arrhythmia.

Genetic studies have identified the specific genetic abnormalities that underpin these diseases, most arrhythmia syndromes are inherited in an autosomal dominant manner, such that first-degree family members have a 50% chance of inheriting the disease. Identification of the mutation allows for predictive genetic testing in other living family members.