Overview

Test Name

Hereditary Cancer High Risk Panel

Test Code

HCE1005

Test Category

Gene Panels

Test Subcategory

Hereditary Cancer

Disease(s) Targeted

cancer

Who Is The Test For?

Patients with a family history, clinical suspicion, or diagnosis of cancer.

Test Approach

Whole exome sequencing (WES) with in silico gene panel analysis

No. of Genes

Panel Content

APC, ATM, BAP1, BMPR1A, BRCA1, BRCA2, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, MEN1, MLH1, MSH2, MSH6, MUTYH, PALB2, PMS2, POLD1, POLE, PTEN, RAD51C, RAD51D, RET, SMAD4, STK11, TP53, VHL

Mitochondrial Genome Included In The Analysis

Deliverables

Clinical Report (Download a sample report here)

Turnaround Time

~3-6 weeks*

Specimen Requirements

For detailed information about the sample requirements, please consult our clinical sample requirements page.

*Turnaround times are estimated from receipt of satisfactory specimen and test request form at the laboratory to release of clinical report. The turnaround time may vary depending on the nature of the specimen and the complexity of the investigation required. The above table is only a guideline and the complexity of a case and the requirement for further investigations may change this.

About cancer

Hereditary cancer is caused by inherited genetic variants passed down through families, which increases the risk of developing certain cancers, typically accounting for 5-10% of all cancer cases. Common hereditary cancers include breast, ovarian, and colorectal cancer. Hereditary cancers are often linked to inherited variants in genes that help control cell growth and division. Well-known examples are the BRCA1/BRCA2 genes for breast and ovarian cancer, and the APC gene for Familial Adenomatous Polyposis (FAP) of the colon.

This panel may be an option when the patient has high risk of having or developing an hereditary cancer. Hereditary cancer is suspected when there is family history of the same cancer or related forms of cancer, early age of onset, multiple cancers in an individual, bilateral (cancers occurring in both paired organs - e.g., both breasts, both kidneys) or multifocal cancers (multiple tumours in the same organ), rare or unusual tumourswhich are strongly associated with hereditary syndromes. This panel includes the genes more frequently associated with hereditary cancer. For a more comprehensive analysis, we recommend using our Comprehensive Hereditary Cancer Panel which contains all genes included on this panel and more.