Dilated Cardiomyopathy (DCM) and Conduction Defects - Expanded Panel

Overview

Test Name

Dilated Cardiomyopathy (DCM) and Conduction Defects - Expanded Panel

Test Code

CAE1008

Test Category

Gene Panels

Test Subcategory

Cardiology

Disease(s) Targeted

Dilated Cardiomyopathy (DCM) and Conduction Defects

Who Is The Test For?

Patients with a family history, clinical suspicion, or diagnosis of Dilated Cardiomyopathy (DCM) and Conduction Defects

Test Approach

Whole exome sequencing (WES) with in silico gene panel analysis

No. Of Genes

Panel Content

ABCC9, ACTC1, ACTN2, BAG3, CRYAB, CSRP3, DES, DMD, DSG2, DSP, EPG5, EYA4, FKTN, FLNC, GATAD1, HAMP, HFE, HJV, IDH2, JPH2, LAMA4, LDB3, LMNA, MT-ATP6, MT-ATP8, MT-CO1, MT-CO2, MT-CO3, MT-CYB, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6, MT-RNR1, MT-RNR2, MT-TA, MT-TC, MT-TD, MT-TE, MT-TF, MT-TG, MT-TH, MT-TI, MT-TK, MT-TL1, MT-TL2, MT-TM, MT-TN, MT-TP, MT-TQ, MT-TR, MT-TS1, MT-TS2, MT-TT, MT-TV, MT-TW, MT-TY, MYBPC3, MYH6, MYH7, MYPN, NEXN, PLN, PPCS, PPP1R13L, PRDM16, PSEN1, PSEN2, RAF1, RBM20, SCN5A, SDHA, SGCD, SLC40A1, SPEG, TAFAZZIN, TCAP, TFR2, TNNC1, TNNI3, TNNI3K, TNNT2, TPM1, TTN, VCL

Mitochondrial Genome Included In The Analysis

Yes

Deliverables

Clinical Report (Download a sample report here)

Turnaround Time

~3-6 weeks*

Specimen Requirements

For detailed information about the sample requirements, please consult our clinical sample requirements page.

Alternative Panels Available

This is the expanded panel for Dilated Cardiomyopathy (DCM) and Conduction Defects. We also offer a core panel which includes 16 less genes (72 genes in total). See test details for the Dilated Cardiomyopathy (DCM) and Conduction Defects - Core Panel.

*Turnaround times are estimated from receipt of satisfactory specimen and test request form at the laboratory to release of clinical report. The turnaround time may vary depending on the nature of the specimen and the complexity of the investigation required. The above table is only a guideline and the complexity of a case and the requirement for further investigations may change this.

About Dilated Cardiomyopathy (DCM) and Conduction Defects

Cardiomyopathies are a heterogeneous group of pathologies of the heart which may affect its size, shape and/or thickness. Common cardiomyopathies include hypertrophic cardiomyopathy and dilated cardiomyopathy.

Conduction defects refer to abnormalities in the electrical conduction system of the heart, which is responsible for coordinating the heart's rhythm and ensuring that the heart muscles contract in a synchronized manner to effectively pump blood.

Cardiomyopathy is a clinically heterogenous disease, and one of the factors that differentiates clinical phenotypes is genotype.