Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) Panel

Overview

Test Name

Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) Panel

Test Code

CAE1004

Test Category

Gene Panels

Test Subcategory

Cardiology

Disease(s) Targeted

Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)

Who Is The Test For?

Patients with a family history, clinical suspicion, or diagnosis of CPVT.

Test Approach

Whole exome sequencing (WES) with in silico gene panel analysis

No. Of Genes

Panel Content

CALM1, CALM2, CALM3, CASQ2, KCNJ2, RYR2, TECRL, TRDN

Mitochondrial Genome Included In The Analysis

Deliverables

Clinical Report (Download a sample report here)

Turnaround Time

~3-6 weeks*

Specimen Requirements

For detailed information about the sample requirements, please consult our clinical sample requirements page.

*Turnaround times are estimated from receipt of satisfactory specimen and test request form at the laboratory to release of clinical report. The turnaround time may vary depending on the nature of the specimen and the complexity of the investigation required. The above table is only a guideline and the complexity of a case and the requirement for further investigations may change this.

About Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome characterised by adrenergically mediated bidirectional and/or polymorphic ventricular tachycardia. CPVT is a significant cause of sudden death.

The prevalence of CPVT in the general population is estimated to affect about 1 in 10,000 individuals.

Inherited Cases: Given its genetic basis, CPVT often appears in families, particularly in those with a history of sudden cardiac death or unexplained syncope (fainting).

CPVT mainly follows an autosomal dominant pattern of inheritance and several genes have been reported as causative genes for CPVT including the ryanodine receptor gene.